A program-delivery system in which universities partner with community teams to implement evidence-based programs for preventing youth (6th and 7th Graders) substance abuse and other problem behaviors. Each participating community (i.e., town or small city) forms a community team of 8-12 people, which is led by a Cooperative Extension System representative and a public school representative, and includes social service and health agency officials as well as community parents and youth. A state-level team of university researchers then provides the community teams with a menu of evidence-based programs, from which the community teams select one family-focused program to deliver in 6th grade, and one school-based program to deliver in 7th grade. A prevention coordinator team, based in the university Cooperative Extension System, serves as a liaison between the community and state-level teams, providing ongoing, proactive technical assistance to community teams to optimize program delivery and sustainability.